II. Medizinische Klinik und Poliklinik



 

Principal Investigator

Prof. Dr. med. Dieter Saur
II. Medizinische Klinik und Poliklinik
Klinikum rechts der Isar der TU München
Ismaninger Str. 22
81675 München
Germany

Phone: +49 (0)89 4140-2255
Fax: +49 (0)89 4140-7289
E-mail: dieter.saur@tum.de

Laboratory members

  • Dieter Saur
  • Regina Christ
  • Stefan Eser
  • Juliana Götzfried
  • Maren Hieber
  • Sabine Klein
  • Angelika Krömer
  • Mariel Paul
  • Nina Schönhuber
  • Kathleen Schuck
  • Barbara Seidler
  • Chuan Shan
  • Christian Veltkamp
  • Magdalena Zukowska

Research background

Gastrointestinal cancer – Molecular mechanisms of tumor development, maintenance, metastasis and treatment resistance

  • Generation and analysis of genetically engineered inducible and switchable models for gastrointestinal cancer subtypes (pancreatic cancer, colon cancer, bile duct cancer, liver cancer)
  • Tissue specific retroviral gene transfer
  • Discovery of genes and signaling pathways crucial for tumor maintenance, tissue-specific metastasis and treatment resistance
  • Tumor-stroma and tumor-immune system interactions
  • Tumor progression and metastasis of GI cancer
  • Discovery and validation of new targets for treatment of GI cancer

Molecular imaging of gastrointestinal cancer

  • Optical (bioluminescence- and fluorescence) imaging in animal models of GI cancer
  • Molecular endoscopic imaging in humans

Neurogastroenterology

  • Molecular and cellular mechanisms of nitric-oxide signaling in the gut
  • Genetic analysis of interstitial cells of Cajal (ICC) using the Cre/loxP system
  • Genetic basis of motility disorders

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List of publications

  1. Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M,
    Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy AM, Banerjee R,
    Yang F, Lee CL, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varela I,
    Bradley A, Kind A, Schnieke AE, Rodewald HR, Rad R, Schmid RM, Schneider
    G, Saur D. A next-generation dual-recombinase system for time- and
    host-specific targeting of pancreatic cancer. Nat Med. (2014) 20:1340-7.
  2. Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell. (2013) 23:406-20.
  3. Heger K, Seidler B, Vahl JC, Schwartz C, Kober M, Klein S, Voehringer D, Saur D*, Schmidt-Supprian M*. CreERT2 expression from within the c-Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells. Eur J Immunol. (2014) 44(1):296-306. * equal contribution
  4. Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D*, Bradley A*. A Genetic Progression Model of Braf(V600E)-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention. Cancer Cell. (2013) 24:15-29. * equal contribution
  5. Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, Allescher HD, Vanderwinden JM, Hofmann F, Schemann M, Rad R, Storr MA, Schmid RM, Schneider G, Saur D. Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun. (2013) 4:1630.
  6. Groneberg D, Lies B, König P, Jäger R, Seidler B, Klein S, Saur D, Friebe A. Cell-specific deletion of nitric oxide-sensitive guanylyl cyclase reveals a dual pathway for nitrergic neuromuscular transmission in the murine fundus. Gastroenterology. (2013) 145:188-96.
  7. von Werder A, Seidler B, Schmid RM, Schneider G, Saur D. Production of avian retroviruses and tissue-specific somatic retroviral gene transfer in vivo using the RCAS/TVA system. Nat Protoc. (2012) 7:1167-83.
  8. Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A. A porcine model of familial adenomatous polyposis. Gastroenterology (2012) 143:1173-5.
  9. Eser S, Messer M, Eser P, von Werder A, Seidler B, Bajbouj M, VogelmannR,Meining A, von Burstin J, Algül H, Pagel P, Schnieke AE, Esposito I, Schmid RM, Schneider G, Saur D. In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. Proc Natl Acad Sci USA. (2011) 108:9945-50.
  10. Brown KN, Chen S, Han Z, Lu CH, Tan X, Zhang XJ, Ding L, Lopez-Cruz A, Saur D, Anderson SA, Huang K, Shi SH. Clonal production and organization of inhibitory interneurons in the neocortex. Science. (2011) 334:480-6.
  11. von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D. E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology. (2009) 137:361-71.
  12. Seidler B, Schmidt A, Mayr U, Nakhai H, Schmid RM, Schneider G, Saur D. A Cre-loxP based mouse model for conditional somatic gene expression and knock-down in vivo using avian retroviral vectors. Proc Natl Acad Sci USA. (2008) 105:10137-42.
  13. von Burstin J, Eser S, Seidler B, Meining A, Bajbouj M, Mages J, Lang R, Kind AJ, Schnieke AE, Schmid RM, Schneider G, Saur D. Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. Int J Cancer. (2008) 123:2138-47.
  14. Mayr U, von Werder A, Seidler B, Reindl W, Bajbouj M, Schmid RM, Schneider G, Saur D. RCAS-mediated retroviral gene delivery: a versatile tool for the study of gene function in a mouse model of pancreatic cancer. Hum Gene Ther. (2008) 19:896-906.
  15. Saur D, Seidler B, Schneider G, Algül H, Beck R, Senekowitsch-Schmidtke R, Schwaiger M, Schmid RM. CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Gastroenterology. (2005) 129:1237-50.
  16. Saur D, Vanderwinden JM, Seidler B, Schmid RM, De Laet MH, Allescher HD: Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. Proc Natl Acad Sci USA. (2004) 101:1662-7.

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Medical and Master of Science theses

Interested students are welcome to contact via e-mail (dieter.saur@lrz.tum.de) or to drop by the experimental laboratory.

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Grant support

Initiator and Coordinator of the BMBF EndoMed Consortium
Deutsche Forschungsgemeinschaft - German Research Fundation
Deutsche Krebshilfe - German Cancer Aid
Bundesministerium für Bildung und Forschung - Ministry of Education and Science
Kommission für klinische Forschungsprojekte der TUM
Bund der Freunde der Technischen Universität München
Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen
Gesellschaft für Gastroenterologie in Bayern
Bayerische Forschungsstiftung
Novartis-Stiftung für therapeutische Forschung
Fritz-Thyssen Stiftung
Helmholtz Alliance Preclinical Comprehensive Cancer Center
German Consortium for Translational Cancer Research

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Impressum

2013 · Klinikum rechts der Isar der Technischen Universität München